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Translating human genetics into animal models
Tomomi Aida[1][2][3]
[1]Emugen Therapeutics, [2]McGovern Institute for Brain Research, Massachusetts Institute of Technology, [3]Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard

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Genetically modified animal models are essential to interpret functional consequence of human genetics in vivo and evaluate therapeutics in preclinical studies. Here, I discuss our efforts for the development of novel genome editing technologies for the generation of genetically modified non-human primates (NHPs), faithful recapitulation of disease symptoms in these NHPs, and further genome editing strategies empowering rapid in vivo functional research and therapeutic development.
keywords: CRISPR, non-human primate, in vivo genome editing

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Translating human genetics into animal models
Tomomi Aida [1][2][3]
[1] Emugen Therapeutics,[2] McGovern Institute for Brain Research, Massachusetts Institute of Technology,[3] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard