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活性酸素による核酸の酸化に起因する生体の障害とその防御機構の解明　－発がんから神経変性まで－
中別府雄作
[1] 九州大学・生医研、[2] 日本学術振興会・サンフランシスコ研究連絡センター

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DNA and its precursor nucleotides are constantly exposed to the danger of oxidation by reactive oxygen species (ROS) generated during normal metabolism or by environmental exposure. DNA and nucleotides exposed to ROS undergo oxidation, and if not repaired or removed, such modified nucleotides can cause cancer by inducing mutations, or cause degenerative diseases by inducing cell dysfunction or death. In my lecture, I will present our findings on the genomic damage caused by oxidatively modified nucleotides, its defense mechanisms, and pathologies caused by disruption of the defense mechanisms.
keywords: 8-oxoguanine; carcinogenesis; neurodegeneration

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Pathological conditions caused by oxidation of nucleic acids and their defense mechanisms
Yusaku Nakabeppu
[1] Med. Inst. Bioreg., Kyushu Univ. [2] JSPS San Francisco Office